Informatics Publishing Limited

Shashikant R. Pattan ¹, Nachiket S. Dighe ², Deepak S. Musmade ¹, Manisha S. Kedar ¹, Smita K. Parjane ¹, Priyanka P. Gadhave ¹, Manjusha S. Sanap ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), IN
2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, A/PLoni Bk., Taluka -Rahata, Dist-Ahmednagar 413736, IN

Abstract

The present review article on tools for synthesis of natural products is to significantly facilitate organic synthesis of natural products which are of significant biological importance by the implementation of new concepts for catalysis. We focus on the recent development in natural product synthesis with the help of newer methods of organic synthesis.

Keywords

Natural Products, Methods of Synthesis, Combinatorial Chemistry.

Full Text

     

Nachiket S. Dighe ¹, Shashikant R. Pattan ², Deepak S. Musmade ², Abhijeet N. Merekar ³, Manisha S. Kedar ², Deepak K. Thakur ², Pratik V. Patel ²

Affiliations
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, A/PLoni Bk., Taluka -Rahata, Dist-Ahmednagar 413736, IN
2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), IN
3 Department of Pharmaceutics, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), IN

Abstract

Many natural products from marine sources are endowed with promising anti cancer activity, thus representing invaluable leads in the plans for drug discovery. In this context, organic synthesis plays a decisive role in confirming (or revising) the chemical structures of the natural compounds allowing also access to suitable amounts of the target (and its analogs) for structure activity relationship (SAR) investigations. In this overview, we focus on the total and partial synthesis of anti cancer marine metabolites and their related compounds discussing the retro synthetic analysis of the strategies adopted.

Keywords

Marine, Anti Cancer Activity, Synthesis of Dictyostatin.

Full Text

     

Shashikant R. Pattan ¹, Nachiket S. Dighe ², H. V. Shinde ¹, Deepak S. Musmade ¹, Mangesh B. Hole ¹, Vinayak M. Gaware ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), IN
2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar A/P- Loni Bk. Taluka -Rahata, Dist-Ahmednagar 413736, IN

Abstract

The present review article on Umpolung chemistry is to significantly facilitate organic synthesis by the implementation of new concepts for catalysis. We focus on the recent development of N- heterocyclic carbenes mediated organic reaction and its implementation to the synthesis of heterocycles of biological importance.

Keywords

Umpolung, N-Heterocyclic Carbenes, Organomettalic Catalyst.

Full Text

     

Nachiket S. Dighe ¹, Pankaj Shinde ¹, Harshali Anap ¹, Sanjay Bhawar ², Deepak S. Musmade ³

Affiliations
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni 413736, MS, IN
2 Department of Pharmacology, Pravara Rural College of Pharmacy, Loni 413736, MS, IN
3 Department of Pharmaceutical Chemistry, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, MS, IN

Abstract

The synthesis, structure and biological activity of Oxadiazole derivatives have long been the focus of research interests in the field of Medicinal Chemistry. A number of Oxadiazole derivatives have been reported to possess interesting biological activities such as Antimicrobial, Anti-inflammatory and Antifungal activities etc. All synthesized compound were characterized by IR, H¬1-NMR and elemental Analysis. All the compounds were evaluated for Antibacterial and Anti-inflammatory at the concentration of 200 μcg/mL by using cup-plate agar diffusion method. The activity was carried out on different micro-organisms (E.coli, S. aureus, A.niger, C. albicans) measured in terms of zone of inhibition and compared the standard drug Ciprofloxacin and Amphotericin B for antimicrobial activity. All the newly synthesized derivatives were screened for Anti-inflammatory activity by an in-vitro method of Inhibition of protein denaturation using Zaltoprofen as a standard.

Keywords

Anti-Inflammatory, Antimicrobial and Oxadiazole.

Full Text

     

Ravindra B. Saudagar ¹, Nachiket S. Dighe ², Deepak S. Musmade ³, Vinayak M. Gaware ⁴, D. A. Jain ⁵

Affiliations
1 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, M.S., IN
2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni-413736, MS, IN
3 Department of Pharmaceutical Chemistry, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, MS, IN
4 Department of Pharmaceutical Chemistry, College of Pharmacy, Chincholi, MS, IN
5 Department of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, Rajasthan, IN

Abstract

Selective estrogen receptor modulators are the class of a chemical compounds acting on a estrogen receptors. These are selectively inhibit or stimulate the estrogen like actions in various tissues. SERMs play a key role in breast cancer chemoprevention. These agents antagonize estrogens in some tissues and mimic their action in others. The mechanism for tissue selectivity appears to be related to differences in their molecular and three-dimensional structures, which affect the transcriptional activity of the activated estrogen receptor. For example, tamoxifen and toremifene act as estrogen antagonists in breast tissue and as estrogen agonists in the endometrium. The present review article is directed towards highlighting the importance of SERMs in treatment of breast cancer.

Keywords

Selective Estrogen Receptor Modulators (SERM’s), Breast Cancer, Hormone Replacement Therapy (HRT).

Full Text

     

Shashikant R. Pattan ¹, V. D. Pujar ², Nachiket S. Dighe ¹, Deepak S. Musmade ¹, S. N. Hiremath ³, H. V. Shinde ¹, R. B. Laware ¹

Affiliations
1 Pravara Rural College of Pharmacy, Loni-413736, M.S., IN
2 KLE’S College of Pharmacy, Belgaum, IN
3 College of Pharmacy, Chincholi, Nashik, M.S., IN

Abstract

A new series of 2-amino substituted benzothiazoles and their derivatives were prepared by multiple steps. The structures of the synthesized compounds were confirmed by Melting point, TLC, IR, and H¹NMR. The compounds were screened for their anti-inflammatory activity, all the compounds shown promising anti-inflammatory activity.

Keywords

2-Amino-Substituted-Benzothiazoles, Anti-Inflammatory, CHN Analysis.

Full Text

     

Shashikant R. Pattan ¹, Nachiket S. Dighe ¹, Deepak S. Musmade ¹, Vinayak M. Gaware ¹, S. G. Jadhav ¹, Medha A. Khade ¹, S. N. Hiremath ²

Affiliations
1 Pravara Rural College of Pharmacy, Pravaranagar, A/P-Loni Bk-413736, Tal Rahata, Dist Ahmednagar, (MS), IN
2 College of Pharmacy, Chincholi, Nashik, M.S., IN

Abstract

A new series of benzopyrone derivatives were synthesized and the structure of these compounds was established on the basis of spectral data. The title compounds were evaluated for antidiabetic activity. Some of these compounds have shown excellent antidiabetic activity.

Keywords

Benzopyrone, Antidiabetic, CHN Analysis.

Full Text

     

Shashikant R. Pattan ¹, Nachiket S. Dighe ¹, Anand A. Bukitagar ¹, Prerana A. Chavan ¹, Snehlata K. Tambe ¹, Deepak S. Musmade ¹, S. V. Hiremath ²

Affiliations
1 Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, M.S., IN
2 Department of Pharmacology, JNMC, Belgaum, Karnataka, IN

Abstract

A new series of substituted phenylthiazole derivatives were synthesized and the structures of these compounds were established on the basis of spectral and elemental analysis. All the compounds were evaluated for anti-convulsant activity by Maximal Electroshock Induced Convulsions in Rats, Pentylenetetrazole- Induced Convulsions in Rats, and Strychnine Induced Convulsions in Rats methods. Compounds C₁, C₂, C₃, C₄, C₅, D₁, D₂, D₃, D₄, D₅, E₁, E₂, E₃, and E₄ have been found to exhibit excellent anti-convulsant activity.

Keywords

Phenylthiazole, Anti-Convulsant.

Full Text